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| Post Doc. U178/U172 lukas.rimle@unibe.ch |
Investigations into the mode of action of a peptide toxin
Project
In this project, we are currently investigating the mode of action of a peptide toxin that has been shown to be an extremely potent agent against several pathogens. However, the peptide’s toxicity towards mammalian cells has prohibited its use as a drug. There are various derivatives of the toxin which have a similar toxicity against the pathogens but that are significantly less toxic towards mammalian cells. Based on a Structure-Activity Relationship (SAR), we want to decipher important moieties of the peptide toxin for its extraordinary toxicity against mammals.
Publications
Deutschmann S., Rimle L., von Ballmoos C. (2021) Rapid estimation of membrane protein orientation in liposomes. Chembiochem. 2021 Nov, doi: 10.1002/cbic.202100543. Epub ahead of print. PMID: 34763366.
Previous work in the group:
2020 – 2024 PhD student:
Project: Investigations into the mode of action of leucinostatin A and its derivatives on mitochondria and mitochondrial ATP synthase
2018 – 2020 Master student:
Project: Development of a novel method to determine membrane protein orientation in a cell mimicking system